Benzamide, N-[2-[(2-amino-6-methyl-4-pyrimidinyl)amino]-4-pyridinyl]-2,6-dichloro-
RO495
CAS: 1258296-60-4
Molecular Formula: C17H14Cl2N6O
Benzamide, N-[2-[(2-amino-6-methyl-4-pyrimidinyl)amino]-4-pyridinyl]-2,6-dichloro- - Names and Identifiers
Benzamide, N-[2-[(2-amino-6-methyl-4-pyrimidinyl)amino]-4-pyridinyl]-2,6-dichloro- - Physico-chemical Properties
| Molecular Formula | C17H14Cl2N6O |
| Molar Mass | 389.24 |
| Density | 1.517±0.06 g/cm3(Predicted) |
| Solubility | ( < 1 mg/ml refers to the product slightly soluble or insoluble) |
| pKa | 10.48±0.70(Predicted) |
| Storage Condition | -20℃ |
| Use | RO495 is a potent inhibitor of TYK2 with IC50 of 1.5nM on TYK2 as tested in cell-based pharmacological assays。 |
Benzamide, N-[2-[(2-amino-6-methyl-4-pyrimidinyl)amino]-4-pyridinyl]-2,6-dichloro- - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.569 ml | 12.846 ml | 25.691 ml |
| 5 mM | 0.514 ml | 2.569 ml | 5.138 ml |
| 10 mM | 0.257 ml | 1.285 ml | 2.569 ml |
| 5 mM | 0.051 ml | 0.257 ml | 0.514 ml |
Last Update：2024-01-02 23:10:35
Benzamide, N-[2-[(2-amino-6-methyl-4-pyrimidinyl)amino]-4-pyridinyl]-2,6-dichloro- - Reference Information
| biological activity | RO495 (CS-2667) is an effective inhibitor of Non-receptor tyrosine-protein kinase 2 (TYK2). |
| target | TargetValue TYK2 () |
| Target | Value |
Last Update：2024-04-09 02:00:00
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